POS0812 SUBCLAVIAN ARTERIES INVOLVEMENT IN PATIENTS WITH GIANT CELL ARTERITIS: DO WE NEED A MODIFIED HALO SCORE?

Background: EULAR recommendations propose temporal and axillary arteries ultrasound (US) as first-line investigation when predominantly cranial giant cell arteritis (GCA) is suspected. Recently, two novel US scoring systems, the halo count Southend Halo Score, have been developed to quantify extent of inflammation by in GCA. Objectives: To assess whether adding subclavian examination into proposed modified improves diagnostic accuracy GCA its relationship with systemic inflammation. Methods: Retrospective observational study patients referred a fast track pathway (FTP) over 1-year period. Patients underwent exam large vessel (LV) (carotid, axillary) arteries. The was measured count, Score (Image 1). gold standard for diagnosis clinical confirmation after 6 months follow-up. Results: 64 were evaluated FTP, 17(26.5%) had Subclavian involvement present only (29.4% versus 0%,p<0.001) (Table Overall, three scores showed excellent (ROC AUC 0.906, 0.930 0.928, respectively) moderate correlations acute phase reactants (0.35-0.51, p<0.01). However, subgroup presenting LV involvement, found between ESR (rho 0.712, p<0.05), haemoglobin 0.703, p<0.05) platelets 0.734, but not other scores. Figure 1. Proposed vascular arteritis. A. B. C: Modified Table Clinical, laboratory findings included or without confirmation. Total n=64 n=17 n=47 p Age, median (IQR ) 78 (69.3-83) (72.5-83) (66-83) 0.5 Female, n (% 42 (65.6%) 10 (58.8%) 32 (68.1%) 0.491 Temporal artery biopsy positive n=13, no. 5 (38.5%) (50%) 0 (0%) 0.231 18 F-FDG-PET/CT n=14, 7 (62.5%) 2 (33.3%) 0.592 Fulfilling 1990 criteria, 16 (25%) 8 (47.1%) (17%) 0.022 PMR before examination, 21 (32.8%) 4 (23,5%) 17 (36,2%) 0.386 Headache, 31 (48.4%) 12 (70.6%) 19 (40.4%) 0.033 Jaw claudication, (18.8%) 9 (52.9%) 3 (6.4%) <0.001 Ocular ischaemia, (6.3%) (11.8%) (4.3%) 0.285 Abnormal TA (7.8%) (17.6%) 0.112 CRP (mg/dL), 1.7(0-6.5) (2.1-14) 1.1 (0-5.1) 0.001 (mm/h), mean (SD 52.8 (34.6) 68.3 (33.3) 46.8 0.044 Haemoglobin (g/dL), 12.5 (1.7) 11.8 (1.6) 12.7 0.059 Platelets /L, 276.1 (105.8) 323.4 (116.3) 258.7 (97.3) 0.52 Positive findings, (26.6%) 15 (88.2%) 13 (20.3%) 1 (2.1%) Axillary (14.1%) (29.4%) + (7.9%) 0.003 Count, (0-0.75) (1-4.5) (0-0) (0-4.5) (7-22.5)) (0-2.75) (3-13.5) Conclusion: inclusion does improve Nevertheless, it correlates better markers LV-GCA Disclosure Interests: None declared